supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The combination of TA and CDDP induced mitochondria‑mediated apoptosis in HepG2 cells and significantly enhanced the growth inhibitory effect compared with TA or CDDP treatment alone.”
“The results obtained from the present study suggest that the combination of TA and CDDP may exert synergistic anticancer effects and may be a novel adjuvant treatment for liver cancer.”
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis.“Combined treatment with TA and cisplatin was found to induce apoptosis and increase DNA damage in the cisplatin-resistant (SKOV-3 CDDP/R) and cisplatin-sensitive (SKOV-3) human ovarian carcinoma cell lines, respectively.”
“In conclusion, as a PARG inhibitor, TA showed anticancer activity and increased the sensitivity of SKOV-3 cells and SKOV-3 CDDP/R cell lines to cisplatin.”
“ TA was also found to enhance the toxicity of cisplatin in ovarian carcinoma cells associated with the inhibition of poly(ADP-ribose) glycohydrolase (PARG) expression, increase the accumulation of poly(ADP-ribose) (pADPr), following the release of apoptosis-inducing factor, and the activation of caspase-3.”
“MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co‐treatment increases bioavailability of cisplatin.”
“Post‐treatment of tannic acid prevents cisplatin (5 mg/kg) induced nephrotoxicity and decreases poly(ADP‐ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4.”
Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats“When TA (10 mmol/l) was given simultaneously with MMS, 4-NQO and cis-DDP , a potentiating effect on their mutagenicity was observed in males whereas in females no such increase was measured.”
“On the other hand, a significant antiproliferative effect with prominent morphological alteration was detected in the cells treated with a combination of TA and cisplatin at the percentage ratio of 90:10.”
“Synergistic interaction was triggered when TA was combined with cisplatin at percentage ratios of 90:10 and 85:15.”
Tannic acid enhances cisplatin effect on cell proliferation and apoptosis of human osteosarcoma cell line (U2OS).“These results indicate that both gallic and tannic acids could serve as a preventive strategy against cisplatin induced nephrotoxicity.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback