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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cisplatin and Sulfur

supplement:

Sulfur

Research Papers that Mention the Interaction

Recent studies have shown that sulfur-containing antioxidants relieve the dose limiting side effects of cis-diamminedichloroplatinum (CDDP), the most commonly used ionic platinum therapy.
Neurotoxicology  •  1999  |  View Paper
A metallomics approach can be used to probe the mechanisms by which the co-administration of sulfur-containing ‘chemoprotective agents’ can modulate the metabolism of cisplatin in the bloodstream.
Metallomics : integrated biometal science  •  2016  |  View Paper
Assuming that electrostatic effects are dominant, cisplatin should interact more strongly with the sulfur atom of CH3S− and deprotonated CYS-S− than transplatin.
Journal of molecular modeling  •  2009  |  View Paper
During the later stages of reactions of cisplatin with albumin, release of NH3 occurs due to the strong trans influence of Met sulfur , which weakens the Pt-NH3 bonds, and protein cross-linking is observed.
The Journal of Biological Chemistry  •  1998  |  View Paper
Interestingly, cisplatin markedly lowered glutathione S-transferase activity and increased sulfane sulfur level and rhodanese activity in tumor cells.
Pharmacological reports : PR  •  2007  |  View Paper
Furthermore, our results demonstrate a highly significant impact of cisplatin on the redox reactivity of sulfur species.
Analytical and Bioanalytical Chemistry  •  2015  |  View Paper