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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Recent studies have shown that sulfur-containing antioxidants relieve the dose limiting side effects of cis-diamminedichloroplatinum (CDDP), the most commonly used ionic platinum therapy.”
L- and D- methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity.“A metallomics approach can be used to probe the mechanisms by which the co-administration of sulfur-containing ‘chemoprotective agents’ can modulate the metabolism of cisplatin in the bloodstream.”
“Assuming that electrostatic effects are dominant, cisplatin should interact more strongly with the sulfur atom of CH3S− and deprotonated CYS-S− than transplatin.”
“During the later stages of reactions of cisplatin with albumin, release of NH3 occurs due to the strong trans influence of Met sulfur , which weakens the Pt-NH3 bonds, and protein cross-linking is observed.”
“Interestingly, cisplatin markedly lowered glutathione S-transferase activity and increased sulfane sulfur level and rhodanese activity in tumor cells.”
Nephroprotective effect of cystathionine is due to its diverse action on the kidney and Ehrlich ascites tumor cells.“Furthermore, our results demonstrate a highly significant impact of cisplatin on the redox reactivity of sulfur species.”
Comparative study of the oxidation behavior of sulfur-containing amino acids and glutathione by electrochemistry-mass spectrometry in the presence and absence of cisplatin
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