Possible Interaction: Cisplatin and Squalamine

“Although HER-2-overexpressing tumors had more angiogenic and less apoptotic activity than parental cancers, growth of both tumor types was similarly suppressed by treatment with squalamine combined with cisplatin.”

“The results suggest that squalamine is anti-angiogenic for ovarian cancer xenografts and appears to enhance cytotoxic effects of cisplatin chemotherapy independent of HER-2 tumor status.”

“However, when combined with cisplatin or carboplatin, squalamine increased tumor growth delay by > or =1.5-fold in the three human lung carcinoma cell lines compared with cisplatin or carboplatin alone.”

“Repeated cycles of squalamine plus cisplatin administration delayed H460 tumor growth >8.6-fold.”

“ Squalamine plus cisplatin reduced CD31 vessel formation by 25% compared with controls, squalamine alone, or cisplatin alone; however, no inhibition in CD31 vessel formation was observed when squalamine was combined with vinorelbine.”

“ Squalamine as a single agent had only a modest effect on the growth of the primary Lewis lung tumor but increased the tumor growth delays produced by cyclophosphamide, cisplatin , paclitaxel and 5-fluorouracil by 2.4- to 3.8-fold compared with the anticancer drugs alone.”

“While squalamine administration alone produced only a modest effect on the growth of the 13,…, there were increases in tumor growth delay of 1.9- to 2.5-fold when squalamine was administered … with cyclophosphamide, cisplatin and paclitaxel compared with the tumor growth … observed with the chemotherapeutic agents alone.”

“Preclinical studies with squalamine have shown additive benefits in tumor growth delay when squalamine is combined with cisplatin , paclitaxel, cyclophosphamide, genistein or radiation therapy.”