Possible Interaction: Cisplatin and Sodium Selenite

“The results showed that the rate of … in the groups treated with both sodium selenite … cisplatin were significantly increased (p < 0.01) as compared with that in the groups without sodium selenite supplementation … to cisplatin alone at corresponding dose, up to or over the rate of negative control group.”

“This study indicated that sodium selenite supplementation can preclude the inhibition of transformation of T lymphocytes in vitro by cisplatin , regardless the pre-treatment by sodium selenite or co-treatment with cisplatin.”

“Recently, is has been reported that administration of sodium selenite reduces cisplatin toxicity without inhibiting the antitumour activity of cisplatin.”

“It has been reported that high doses of sodium selenite can reduce side effects of cisplatin (CDDP) without compromising its antitumor activity, thus substantially enhancing the cure rate in tumor-bearing mice.”

“Methods to reduce CP nephrotoxicity include the use of sodium selenite.”

“Diethyldithiocarbamate (DDTC), S-2(3-aminopropylamino)ethylphosphorothioic acid (WR-2721), and sodium selenite have all been shown to effectively reduce cisplatin toxicity.”

“ Sodium selenite , 2 mg of selenium per kg, given 1 h before c-DDP , greatly reduced blood urea nitrogen and creatinine levels and morphological kidney damage in both BALB/c mice and Wistar rats, while administration 1 h after c-DDP did not.”

“The present results indicate that sodium selenite may provide protection against c-DDP nephrotoxicity, when it is given before c-DDP.”

“Remarkable protective action of sodium selenite was demonstrated against lethal and renal toxicity of CDDP.”