Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Cisplatin and Silymarin

supplement:

Silymarin

Research Papers that Mention the Interaction

When silymarin was given in different doses before cisplatin , it decreased the toxic effect of cisplatin in the kidney but sclerotic blood vessels remained.
The American journal of the medical sciences  •  2018  |  View Paper
Silymarin may be a potential candidate drug to eliminate cisplatin induced ototoxicity.
International journal of pediatric otorhinolaryngology  •  2014  |  View Paper
Pretreatment with silymarin 2 h before cisplatin significantly decreased the pathological changes induced by cisplatin and appeared highly protective.
These results suggested that silymarin possess protective effects against cisplatin hepatotoxic action in animal models.
Pakistan journal of biological sciences : PJBS  •  2010  |  View Paper
The results obtained suggested that silymarin significantly attenuated the hepatotoxicity as an indirect target of CDDP in an animal model of CDDP-induced nephrotoxicity.
Journal of biochemistry and molecular biology  •  2006  |  View Paper
In some of these studies, Silymarin was shown to have positive effects on preventing or decreasing severity of Cisplatin nephrotoxicity.
Journal of clinical and diagnostic research : JCDR  •  2015  |  View Paper
Pretreatment of animals with silymarin (50 mg kg−1) or extract (0.6 g kg−1) 2 h before cisplatin prevented the tubular damage.
Evidence-based complementary and alternative medicine : eCAM  •  2005  |  View Paper