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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“When silymarin was given in different doses before cisplatin , it decreased the toxic effect of cisplatin in the kidney but sclerotic blood vessels remained.”
Role of Bone Marrow Derived Mesenchymal Stem Cells and the Protective Effect of Silymarin in Cisplatin‐Induced Acute Renal Failure in Rats“ Silymarin may be a potential candidate drug to eliminate cisplatin induced ototoxicity.”
“Pretreatment with silymarin 2 h before cisplatin significantly decreased the pathological changes induced by cisplatin and appeared highly protective.”
“These results suggested that silymarin possess protective effects against cisplatin hepatotoxic action in animal models.”
“The results obtained suggested that silymarin significantly attenuated the hepatotoxicity as an indirect target of CDDP in an animal model of CDDP-induced nephrotoxicity.”
“In some of these studies, Silymarin was shown to have positive effects on preventing or decreasing severity of Cisplatin nephrotoxicity.”
Effect of silymarin in the prevention of Cisplatin nephrotoxicity, a clinical trial study.“Pretreatment of animals with silymarin (50 mg kg−1) or extract (0.6 g kg−1) 2 h before cisplatin prevented the tubular damage.”
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