supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Cisplatin
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Our findings show that HSA CDDP has the potential to be a novel therapeutic agent for SPARC-expressing tumors, enhancing the tumor targeting effect by HSA and reducing the nephrotoxicity of CDDP.”
Efficacy and Safety of Human Serum Albumin–Cisplatin Complex in U87MG Xenograft Mouse Models“Type I agents include cis-diamminedichloroplatinum (II), 4'-(9-acridinylamino)methanesulphon-m-anisidide, neocarzinostatin, nitrogen mustard, adriamycin, daunorubicin and mitomycin C--drugs whose biological activities are reduced in the presence of HA.”
“We noted that cisplatin incubation with HSA resulted in the formation of higher order HSA n‐mers, depending on the amount of cisplatin added.”
“In RNAi A549 cells, however, eHSA no longer weakened but enhanced the anticancer effect of DDP , while no longer altered the effect of VP-16.”
Weakening Impact of Excessive Human Serum Albumin (eHSA) on Cisplatin and Etoposide Anticancer Effect in C57BL/6 Mice with Tumor and in Human NSCLC A549 Cells
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback