Possible Interaction: Cisplatin and Selenium

“The above results suggest that the Se can be used as an agent for reducing the nephrotoxicity and bone marrow suppression induced by cisplatin.”

“Although previous studies have implicated the transient receptor potential vanilloid 1 (TRPV1) cation channel, the synergistic inhibition effects of selenium (Se) and cisplatin in cancer and the suppression of ongoing apoptosis have not yet been investigated in MCF-7 breast cancer cells.”

“In biochemichal analyses, pretreatment with selenium prevented the elevation of MDA levels in Cis+Se group rats.”

“Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect.”

“Although, cisplatin has a peripheral neurotoxic effect in rats, this effect was partially prevented by selenium treatment.”

“Thus, it appears that co-administration of selenium and cisplatin may be a useful approach to decrease severity of peripheral neurotoxicity.”

“The decreased antioxidant enzymes and vitamins and increased MDA levels in the kidney, lens and liver of animals administered with cisplatin were significantly (P<0.05 to <0.001) improved with selenium and a high dose vitamin E injection.”

“ Selenium treatment decreased the effect of CP on serum creatinine, and renal malondialdehyde levels, but did not affect the other parameters with the exception of kidney necrosis which was also diminished by this treatment.”

“We propose here that, with selenium , higher dose administration of cisplatin to patients might be applicable.”

“The groups of mice fed the diets containing 0.009 and 0.1 ppm of selenium showed higher sensitivity to the lethal toxicity caused by a single subcutaneous administration of cis-DDP (32 mumol/kg) than the other groups.”

“These results suggest that the dietary level of selenium affects the manifestation of lethal and renal toxicity of cis-DDP.”

“Electron microscopy showed reduced changes in renal cells when selenium was added to the cis-DDP treatment.”

“Therefore, the addition of selenium allowed the administration of high doses of cis-DDP , which resulted in an improved antitumor effect.”

“These results suggest that the addition of selenium decreases the nephrotoxicity of cis-DDP.”

“treatment of tumor-bearing animals with 2 or 4 micrograms of selenium reduced the early mortality induced by cis-DDP at a dose of 16 micrograms/g.”