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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“In vitro, cisplatin significantly increases the expression of TPMT and metabolic genes clustered around the key methyl donor substrate for TPMT, S-adenosyl-methionine.5 Lanvers-Kaminsky et al. note that longer follow-up times may be required to replicate these genetic associations.”
Response to “Evaluation of Pharmacogenetic Markers to Predict the Risk of Cisplatin‐Induced Ototoxicity”“However, a significant increase in renal dysfunction was induced by SAM in animals treated with cisplatin.”
“The present study also demonstrated that the combination of AdoMet and cisplatin synergistically inhibited HNSCC cell migration.”
“These results demonstrate that AdoMet has ER‐stress‐mediated antiproliferative activity and synergizes with cDDP on cell growth inhibition, thus providing the basis for its use in new anticancer strategies.”
“These studies suggest that inhibition of S-adenosylmethionine dependent transmethylation enhanced the toxicity of cisplatin and carboplatin to human ovarian carcinoma cells in vitro without directly affecting the metabolism of either platinum drug.”
Synergy between cisplatin and an inhibitor of S-adenosylmethionine dependent transmethylation in human ovarian adenocarcinoma cells.
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