Possible Interaction: Cisplatin and Quercetin

“In 9 of 11 patients, … inhibited following administration of quercetin at 1 h, which persisted to … patient with ovarian cancer refractory to cisplatin , following two courses of quercetin (420 mg/m2), the CA 125 had fallen … units/ml, and in another patient with hepatoma, the serum alpha-fetoprotein fell.”

“In summary, our results indicate … the simultaneous combination of cisplatin , metformin, and quercetin may synergistically inhibit the growth of Sune-1 cells and subcutaneous xenografts in nude mice through their different anticancer mechanisms, which may be clinically refractory and provide reference for chemotherapy of patients with recurrent nasopharyngeal carcinoma.”

“… cisplatin, … quercetin all had significant inhibitory effects on the proliferation of Sune-1 cells and the growth of subcutaneous xenografts in nude mice ( P < 0.01), … ( P < 0.05), the contribution level of each drug in the three-drug combination application from high to low were cisplatin > metformin > quercetin.”

“Clonal assay also indicated that combined treatment with QU and CP is lethal to bladder cancer cells in both conditions.”

“Our results demonstrate that combined treatment with CP and QU may increase death of tumor cells in physiological and hyperthermic conditions which could be clinically relevant in locoregional chemotherapy.”

“ QU acted in additive or synergistic manner in combination with CP between physiological condition and hyperthermia.”

“ Quercetin (QU), a hyperthermic sensitizer, when combined with cisplatin (CP) affects tumor growth.”

“There is mounting evidence to suggest that quercetin has potential anticancer effects and appears to interact synergistically when used in combination with approved chemotherapeutic agents such as irinotecan and cisplatin.”

“Our results suggest that in a cancer model in vivo, the protection exerted by quercetin on cisplatin nephrotoxicity is related to its antioxidant, vascular, anti-inflammatory and antiapoptotic effects, but these properties do not affect the mechanisms responsible for the antitumour effect of cisplatin.”

“In a xenograft mouse model of ovarian cancer, Qu enhanced the antitumor effect of cDDP.”

“Meanwhile, Qu markedly reduced the elevation of blood creatinine during cDDP intervention.”

“Therefore the strategy of Qu pretreatment may be beneficial in enhancing the therapeutic efficacy of cDDP against ovarian cancer.”

“These data indicate that Qu pretreatment potentiates the antitumor effects of cDDP in ovarian cancer while protecting the kidneys against damage.”

“Tumors from mice treated with cDDP in combination with Qu pretreatment had repressed STAT3 phosphorylation, lower BCL‐2 and higher apoptosis levels compared with those from the other groups.”

“We found that Qu pretreatment significantly enhanced cDDP cytotoxicity in an ovarian cancer cell line and primary cancer cells.”

“Conclusion Taken together, these data suggest that Quercetin at low concentrations attenuate the therapeutic effects of Cisplatin and other anti-neoplastic drugs in ovarian cancer cells by reducing ROS damage.”

“In xenogeneic model, Quercetin led to a substantial reduction of therapeutic efficacy of Cisplatin along with enhancing the endogenous antioxidant enzyme expression and reducing ROS-induced damage in xenograft tumor tissue.”

“Targeting this axis using Qu combined with Cis may be a treatment strategy to improve prognosis in patients with OSCC.”

“The combination of Qu and Cis can reduce tumor growth and decrease drug resistance in OSCC.”

“A combination of 4 mg or 5 mg cis‐DDP with 20 mg quercetin per kg body weight also reduced tumor growth compared to single cis‐DDP treatment.”

“Concomitant treatment with 20 mg quercetin and 3 mg cis‐DDP per kg body weight reduced tumor growth to a significantly greater degree than cis‐DDP alone.”

“Besides, quercetin combined with cisplatin group induced more cell apoptosis in contrast to single-drug group.”

“Conclusion Quercetin and cisplatin had synergistic inhibitory effect on cervical cancer cells.”

“ Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells.”

“The effect of combination of quercetin and cisplatin on cell proliferation was stronger than their individual effects.”