Possible Interaction: Cisplatin and Potassium

“Our study identified two compounds, namely potassium antimony tartrate and topotecan, that significantly enhanced the sensitivity of colorectal and non-small cell lung cancer cells to CDDP.”

“The potassium currents were enhanced to 192< by the application of cisplatin (0.5 mM).”

“ Cisplatin caused a significant decrease in glomerular filtration rate (GFR), urine osmolarity, and urinary excretion rate of potassium , but significant increase in the kidney index and histological damage compared with the control group.”

“Results showed that cisplatin injection caused significant decreases in the serum sodium (Na+), potassium (K+), bicarbonate (HCO3-), calcium (Ca2+), phosphate (PO42-) and concomitant significant increases in the serum urea and creatinine levels.”

“PurposeAdministration of cisplatin causes changes in magnesium and potassium metabolism.”

“Decreased urinary levels of glucose, sodium and potassium reflected a protective action against the renal dysfunction caused by cisplatin.”

“There was a significant rise in potassium (K+), sodium (Na+), and chlorine (Cl−) in the endolymph of the animals treated with CDDP as compared with the control animals.”

“Tubular fluid sodium, chloride, and potassium concentrations were lower at the papillary tip in cis-platinum treated rats (p less than 0.01).”

“ Cisplatin , an effective anti-tumor agent, has significant effects on renal function including reduced glomerular filtration rate and potassium and magnesium wasting.”

“Intracellular effects of cisplatin cause tubular damage and tubular dysfunction with sodium, potassium , and magnesium wasting.”