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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Polyphenols
Research Papers that Mention the Interaction
“Interestingly, the combination of bound polyphenols and CDF-DF ( CDDP ) could recover these indexes influenced by the removal of bound polyphenols in in vitro fermentation samples.”
The effect of bound polyphenols on the fermentation and antioxidant properties of carrot dietary fiber in vivo and in vitro.“Besides, TPs reduce the nephrotoxicity induced by cisplatin , ameliorate irinotecan-induced side effects in the small intestine of mice, and decrease bleomycin-caused DNA damage in human leukocytes.”
“Also, there is a growing body of evidence about the combined treatment of OOPs with various anticancer drugs, such as cisplatin , tamoxifen, doxorubicin and others.”
“The combined TPP and CP treatment synergistically induced apoptosis through both caspase‐8 and caspase‐9 activation and p53 over‐expression.”
“ Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin , and induce apoptosis and/or cell-cycle arrest.”
Polyphenols enhance the activity of alkylating agents in leukaemia cell lines
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