Possible Interaction: Cisplatin and Phenethyl Isothiocyanate

“ Phenylethyl isothiocyanate (PEITC), a natural compound found in watercress, could enhance the efficacy of CDDP by degrading Mcl-1.”

“ PEITC inhibited cisplatin‐resistant human SGC7901/DDP cell growth in a dose‐dependent manner, causing increased apoptosis, ROS generation, glutathione depletion, accumulation of Rhodamine‐123, decreased expression of P‐glycoprotein and cell cycle arrest.”

“Finally, we demonstrated that Noxa induction was associated with apoptosis induced by PEITC plus cisplatin.”

“In NCI-H596 cells, 20 microM benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) enhance the efficacy of various concentrations of cisplatin , but sulforaphane (SFN) does not.”

“In conclusion, the results of the present study showed that PEITC displayed anti-cancer effects, … the tumor initiation, suggesting a chemopreventive effect in gastric cancer, and that pretreatment of PEITC potentiated … of cisplatin , possibly by reducing the intracellular pool of glutathione, … combination strategy of chemotherapy with pretreatment with PEITC.”

“ Phenethyl isothiocyanate alone was sufficient to cause nucleus condensation and fragmentation and induce apoptosis in cervical cancer cells, but evident synergistic effects were observed in combination with cisplatin.”