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Last Updated: 2 years ago

Possible Interaction: Cisplatin and Panax Notoginseng

Research Papers that Mention the Interaction

PNS (50-200 µg/mL) significantly enhanced cisplatin cytotoxicity, but this effect required functional gap junctions between the cells.
These results suggest that PNS increases the cytotoxicity of cisplatin through enhancement of GJ activity.
Biological & pharmaceutical bulletin  •  2012  |  View Paper
In addition, PNS suppressed the induction of apoptosis and ROS production following cisplatin treatment.
PNS may serve as a potential candidate in regulating cisplatin‑induced cytotoxicity.
These findings suggested that PNS protected auditory cells against ototoxicity induced by cisplatin by activating AKT/Nrf2 signaling.
Molecular medicine reports  •  2020  |  View Paper
In addition, PNSs increased the levels of superoxide dismutase, catalase and glutathione, as well as ATP and mitochondrial membrane potential in renal tissues; these are all reduced by cisplatin and further reduced by HIF‐1α inhibition.
In conclusion, we demonstrate here that PNSs protects against mitochondrial damage induced by cisplatin through HIF‐1α/mitochondria/ROS.
We observed that PNSs remarkably reduced the levels of ROS, malondialdehyde and nitric oxide, as well as the opening of mitochondrial permeability transition pore, which is increased by cisplatin and further increased by HIF‐1α inhibition.
FEBS open bio  •  2019  |  View Paper
Moreover, PNS treatment decreased the CDDP or CDDP plus HIF-1α-knockdown-induced elevation of apoptosis and apoptosis-associated protein expressions.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2021  |  View Paper