Possible Interaction: Cisplatin and Niacin

“We demonstrated that NAM reduces PARP activity in vitro, and in cells subjected or not to DNA damage, it also reduces the viability of breast cancer cell lines and synergyzes the cytotoxicity of cisplatin in MDA-MB-436 and MCF-7 cells.”

“Further, inactivation of endogenic Sirt1 by nicotinamide markedly increased chemo-sensitivity in cisplatin resistant sub-cell line Tca8113/CDDP.”

“There are interesting similarities between the actions of nicotinamide and cisplatin.”

“The mean survival times of the mice increased from 21.2–37.0 days in DDP-treated groups to 47.0–54.6 days in mice treated with DDP plus NA or 3AB.”

“The pathological study revealed that the morphologic changes in the proximal tubules 1 month after a single dose of DDP (10 mg/kg) were partially prevented by a single protective dose (5 mmol/kg) of NA or 3AB.”

“The single-dose lethality of DDP on mice was partially reversed by either NA or 3AB.”

“These drugs … potentiated DDP antitumor activity on sarcoma 180, with the inhibition rates increasing from 12.4%–20.8% in groups treated daily with DDP to 29.8%–46.4% in those treated with DDP plus NA or 3AB; however, neither 3AB nor NA alone showed any antitumor activity.”

“At a … mM, nicotinamide (NA), an inhibitor of poly(ADP-…), significantly potentiated the cytotoxicity of cisplatin (DDP) in a DDP-resistant rat ovarian tumor cell line (O-342/DDP) in vitro, whereas the … no substantial effect on DDP's cytotoxic activity against the DDP-sensitive parental line (O-342).”

“These results suggest that NA might have some clinical potential in reversing DDP resistance, and further studies are therefore warranted to confirm the resistance-reversing effect of NA in other DDP-resistant cell lines.”

“… nicotinic acid had distinct inhibitory effects on the …, namely, mitomycin C, bleomycin, fluorouracil, cis-Diaminodichloroplatinum , arabinosylcytosine and mustargen Vit K3 showed inhibitory effect to mitomycin C, fluorouracil, cis-diaminodichloroplatinum, and arabinosylcytosine but … B2, Vit Bco, Vit D3, Vit E, Rutin, Vit K1, Vit K4 and folic acid did not.”