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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“Simultaneously, the activities of NAD + -dependent IDH, mitochondrial aspartate aminotransferase, and two malate dehydrogenase isoenzymes, whose genes were not predicted to have the p53-binding sequences near the transcription starting points, were upregulated by cisplatin.”
Regulation of Thiamine (Vitamin B1)-Dependent Metabolism in Mammals by p53“In conclusion, we demonstrated that modulation of NAD+ biosynthesis via the de novo synthesis pathway and the salvage synthesis pathway could both prevent ototoxicity of cisplatin.”
“In our investigates, we observed that NAD+ level was changed in the cochlear explants of mice treated with cisplatin.”
Modulation of NAD+ biosynthesis activates SIRT1 and resist cisplatin-induced ototoxicity.“Mechanistically, cisplatin inhibited expression of the NAD+ biosynthesis rate-limiting enzyme nicotinamide phosphoribosyl transferase (Nampt).”
“Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD+) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.”
Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments
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