supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Cisplatin
supplement:
Methionine
Research Papers that Mention the Interaction
“Although Met could slightly increase the rate of platination of cis-DDP to guanosine monophosphate (GMP), the reaction with synthetic DNA showed that the presence of Met actually inhibited platination on both single strand (ss) and double strand (ds) DNA.”
“Here we report that both isomers of the sulfur-containing antioxidant methionine MET ) completely block the in vivo ototoxic and nephrotoxic effects of CDDP , and the duration of MET otoprotection is longer than has been previously reported.”
“The MX-t tumor was relatively resistant to both methionine starvation and cisplatin alone but was very sensitive to the combination of methionine starvation and cisplatin with a 32.1% T/C ratio.”
“This report demonstrates that methionine depletion can strongly modulate the efficacy of cisplatin against the MX-t human breast carcinoma cell line when grown in nude mice.”
“For both cell lines, methionine depletion reduces their sensitivity to a range of chemotherapy agents that interface at the level of methionine metabolism, namely temozolomide, cisplatin and methotrexate.”
“ M ) increased the apoptosis induced by cisplatin alone from 18.7% to 42.2% in HeP2 cells.”
Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer“ Methionine greatly increased inhibition by cisplatin but provided minimal protection in the case of chloroplatinic acid.”
“Diethyldithiocarbamate, potassium cyanide (KCN), sodium thiocyanate, L-methionine , N-acetyl-L-cysteine, 2-aminoethanethiol, L-cysteine, L-lysine, L-histidine, and L-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum(II)-protein binding in the in vitro model system.”
“ D‐methionine has an appetite‐enhancing effect and alleviates weight loss during cisplatin treatment.”
D‐methionine improves cisplatin‐induced anorexia and dyspepsia syndrome by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration“RESULTS Ci platin in jection resulted in increases of ROS production, met hionine oxidation, a nd oxidative damage in the kidneys.”
“In contrast, conversion of the methionines increased the uptake and cytotoxicity of cDDP well above that attained with wild-type hCTR1.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback