Possible Interaction: Cisplatin and Magnesium

“The concentration of magnesium in serum has been shown to fall to potentially dangerously low levels after several courses of treatment with cis-diamminedichloroplatinum II (cis-platin).”

“While magnesium status did not interfere with tumor killing by cisplatin, it significantly affected renal function following cisplatin.”

“A number of drugs have been shown to alter magnesium handling ; these include antibiotics such as gentamicin, antineoplastic agents such as cisplatin and immunological suppressive drugs such as cyclosporin.”

“In addition, the administration of magnesium and mannitol may assist in maintaining renal function and reducing nephrotoxicity in adults receiving cisplatin.”

“Urine neutrophil gelatinase‐associated lipocalin to urine creatinine ratio (NGAL/Cr) and urinary magnesium and potassium wasting increased significantly after cisplatin infusion in both groups.”

“Amifostine, calcium and magnesium , glutathione, and vitamin E showed modest but promising (borderline statistically significant) results favouring their ability to reduce the neurotoxicity of cisplatin and related chemotherapies, as measured using secondary, non-quantitative and subjective measures such as the NCI-CTC neuropathy grading scale.”

“Moreover, it was found a sub-group of MGs including ASS1, JUNB, PTGS2, EEF2, SULF1, TOP2A, AURKA, BIRC5, CAV1, IFITM1, PCNA, and PKM2 that could explain, at least in part, the mechanisms of resistance to cisplatin , one first-line chemotherapeutic drug used for the disease.”

“Within an oncology setting, certain chemotherapy drugs, such as cisplatin , may lead to magnesium loss causing nephropathy.”

“ CPL has been shown to result in renal magnesium loss and reduced glomerular filtration rate, and its toxicity clearly differs from IFO-mediated tubulopathy.”

“We conclude that cisplatin alters renal tubular handling of magnesium , resulting in significant prolonged dose-related hypomagnesemia.”