Possible Interaction: Cisplatin and Lycopene

“However, administration of lycopene in combination with cisplatin resulted in a reduction in the serum urea-N (124.3 vs. 62.4) and creatinine (1.37 vs. 0.40) levels and the kidney efflux transporters MRP2 and MRP4 proteins in the kidneys.”

“The analyses of the results revealed statistically significant differences between two groups (p < 0.05), suggesting lycopene ’s possible protective effect against cisplatin ototoxicity.”

“On the other hand, cisplatin mediated increase in NF-kappaB p65 was brought down by lycopene.”

“This study reports that lycopene mitigates the nephrotoxic effect of cisplatin in rat through Nrf2-mediated induction of heme oxygenase-1 (HO-1).”

“Both LCP and CAPE were able to mitigate the changes, to a different extent, in oxidative damage and apoptosis progression induced by cisplatin.”

“CONCLUSION Ly opene in creases the sensitization of cervical cancer cells to cis platin vi a inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression.”

“Conclusion Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression.”

“Results We found that lycopene acts as a synergistic agent with cisplatin in preventing the growth of HeLa cells.”

“The inhibitory effect of cisplatin was enhanced with lycopene addition by declining the cell viability to 37.4% (P < 0.0001).”

“The results of the present study suggest that lycopene and concurrent cisplatin chemotherapy might have a role in improving the treatment of cervical cancer.”

“The results of the present study suggest that lycopene and the concurrent cisplatin chemotherapy might have a role to improve the treatment of cervical cancer.”