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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ LE and GA also inhibited p53 expression and its phosphorylation as well as ROS production in cells exposed to cisplatin.”
Licorice and its active compound glycyrrhizic acid ameliorates cisplatin-induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells.“However, cancer patients with cisplatin therapy should avoid the supplementation of the licorice extract.”
“The administration of the licorice extract plus cisplatin recovered these functional indices in the kidney and liver to almost the control levels.”
“The combination of the licorice extract and cisplatin diminished the therapeutic efficacy of cisplatin but promoted considerably antitumor activity of the licorice extract.”
Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer.
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