Possible Interaction: Cisplatin and Levocarnitine

“Conclusions: CDDP transiently increased plasma LC levels.”

“In preclinical studies, cisplatin and carboplatin were shown to reduce L-carnitine and cause mtDNA mutations, and doxorubicin was also found to cause mtDNA mutations.”

“However, l-carnitine , vitamin C, or their combination significantly attenuated the alterations caused by CIS in the plasma and kidneys of the rats.”

“However, the administration of both vitamin C and l-carnitine , and not either of the two showed additive effects in attenuating the adverse effects of cisplatin.”

“ L-carnitine may reduce late testicular and spermatic damage caused by cisplatin administration to prepubertal rats by inducing germ cell proliferation and preventing apoptosis.”

“Conclusion: L-carnitine resolves the cisplatin-induced urinary concentration defect, which may occur by increasing AVP/cyclic adenosine monophosphate/AQP2 levels, indicating the potential use of L-carnitine to ameliorate the renal urinary concentration effect in cancer patients treated with cisplatin.”

“These results indicate that L-carnitine may have therapeutic potential for inhibiting the side effects of cisplatin and other anticancer agents in the kidney and small intestine.”