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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Conclusions: The current evidence prompted that Lentinan combined with cisplatin in thoracic injection might benefit patients with NSCLC on a certain extent; this systematic review revealed some definite conclusions about the application of Lentinan combined with cisplatin in thoracic injection for NSCLC.”
Lentinan combined with cisplatin for the treatment of non-small cell lung cancer“BACKGROUND Many studies have investigated the efficacy and safety of lentinan combined with cisplatin versus cisplatin alone for controlling malignant pleural effusion (MPE).”
“In addition, lentinan combined with cisplatin showed a better benefit of quality of life (QOL) compared with cisplatin alone (P < 0.001).”
“RESULTS The overall response rate (ORR) of le tinan co mbined with cis platin fo r controlling MPE was significantly higher than that of cisplatin alone (P < 0.001).”
“ Lentinan has the ability of inducing BGC823 cell apoptosis and this effect is enhanced when combined with docetaxel and cisplatin.”
“These results indicated that lentinan administration decreases tissue GST‐II and GST‐III contents and enhances the sensitivity of colon 26 tumor to CDDP.”
Lentinan Enhances Sensitivity of Mouse Colon 26 Tumor to cis‐Diamminedichloroplatinum(II) and Decreases Glutathione Transferase Expression“In addition, lentinan and cisplatin co-treatment induced mitochondrial depolarization.”
“This suggested that lentinan combinatorial therapy with cisplatin engaged a different signalling pathway to kill the liver cancer cells and that adjuvant therapy with lentinan can reduce the dose of cisplatin and thus reduce the possibility of chemo-resistance.”
“We also showed that lentinan hugely reduced the dose of cisplatin to induce certain amount of death and that lentinan co-treatment with cisplatin enhanced the Apaf1 transcription in HepG2 cells while lentinan or cisplatin alone failed to alter the transcription.”
Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells.“ Lentinan … cisplatin significantly improved complete response [Risk ratio (RR) = 1.68, 95% confidence intervals (CI) (1.51 to 1.87), p < 0.00001, Fig.3a] and … (1.41 to 1.62), p < 0.00001, Fig.4], and decreased the risk of treatment failure, myelosuppression, gastrointestinal reaction, and chest pain.”
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