Possible Interaction: Cisplatin and Kaempferol

“Furthermore, the inhibition of THOC1 activity by luteolin enhances the chemosensitivity of HCC tumor cells to cisplatin.”

“ Luteolin combined with cisplatin can effectively suppress HCC tumor growth, indicating a potential and effective therapeutic strategy that uses luteolin in combination with conventional cytotoxic agents for HCC treatment.”

“Flow cytometry revealed that luteolin enhanced cell apoptosis in combination with cisplatin.”

“In addition, wound-healing assay and Matrigel invasion assay showed that luteolin and cisplatin synergistically inhibited migration and invasion of CAOV3/DDP cells.”

“Furthermore, luteolin enhanced the anti-cancer effect of cisplatin.”

“Moreover, … that luteolin is a potent … cytotoxicity of cisplatin in LNM35 cells and decreases the growth of LNM35 tumor xenografts in athymic mice after intraperitoneal injection (20mg/kg/day … combination with standard anticancer drugs such as cisplatin, may be a promising HDAC inhibitor for the treatment of lung cancer.”

“Finally, by using an in vivo nude mice xenograft model, we confirmed that luteolin enhanced the cancer therapeutic activity of cisplatin via p53 stabilization and accumulation.”

“Additionally, our in vitro data indicated that kaempferol may sensitize head and neck tumor cells to the effects of cisplatin.”

“In this study, luteolin was found to suppress autophagy with reduced expression of LC3-II, but enhanced the inhibition of cell vitality and promoted apoptosis induced by cisplatin , leading to restoration of the sensitivity to cisplatin in ovarian cancer cells through CCK-8, flow cytometry and immunofluorescent assays.”

“Our present work demonstrate that LUT can suppresses autophagy but enhance apoptosis induced by cisplatin and promote the sensitivity to cisplatin through suppressing the expression of RARP1 in ovarian cancer.”

“Treatment with a specific Nrf2 inhibitor, luteolin , significantly sensitized A549 cells to BON and DDP and increased BON- or DDP-induced apoptosis.”

“ Luteolin inhibited Nrf2 and markedly enhanced cytotoxicity in combination with Cis.”

“It was also demonstrated that a combinational treatment of cisplatin and luteolin induced more effectively cell growth inhibition, compared to cisplatin treatment alone.”