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Last Updated: 3 years ago

Possible Interaction: Cisplatin and Isothiocyanate

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drug:

Cisplatin

supplement:

Isothiocyanate

Research Papers that Mention the Interaction

“Pretreatment of gastric cancer cells with ITCs enhanced the inhibitory effects of cisplatin (but not 5-fluorouracil) in time- and concentration-dependent manners.”

Chemopreventive Effects of Dietary Isothiocyanates in Animal Models of Gastric Cancer and Synergistic Anticancer Effects With Cisplatin in Human Gastric Cancer Cells

Frontiers in Pharmacology • 2021 | View Paper

“Although in vitro studies have shown that isothiocyanates (ITCs) can synergistically sensitize cancer cells to cisplatin treatment, the underlying mechanisms have not been well defined, and there are no in vivo demonstrations of this synergy.”

Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo.

American journal of cancer research • 2015 | View Paper

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