supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Ih636 Grape Seed Proanthocyanidin Extract
Research Papers that Mention the Interaction
“The presence of GSPE with cisplatin significantly alleviated its nephrotoxicity.”
“Thus, GSPE may be used to prevent toxicity during chemotherapeutic treatment with cisplatin.”
“While, GSPE treatment protected against the toxic effects induced by cisplatin.”
Cisplatin induced damage in kidney genomic DNA and nephrotoxicity in male rats: the protective effect of grape seed proanthocyanidin extract.“Therefore, the present results revealed that GSPE exerts a protective effect by antagonizing cisplatin toxicity.”
“Besides, GSPE reversed the downregulation of PI3K, p-PI3K, Akt, p-Akt, mTOR, and p-mTOR protein expression induced by CIS.”
“In conclusion, the evidence suggested that GSPE can act as a protective agent against testicular toxicity induced by CIS.”
“Our findings suggest that GSPE may be a novel protective agent against testicular toxicity induced by CIS.”
Grape seed proanthocyanidin extract ameliorates cisplatin-induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats.“Thus, it can be concluded that the consumption of GSPE or FO might be useful for preventing nephrotoxicity caused by cisplatin treatment.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback