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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cisplatin and Hydroxytyrosol

supplement:

Hydroxytyrosol

Research Papers that Mention the Interaction

HT alleviated the levels of reactive oxygen species in both untreated state and after cisplatin stimulus.
…,HT at concentration of 100 μM decreased the cell viability of HEI-OC1 from 100 ± 17.38% in control group to 50.17 ± … ± 0.050 in the control group to 1.24 ± 0.18, 0.85 ± 0.18 in the group treated with 30 μM cisplatin , as well …, respectively.
European journal of pharmacology  •  2020  |  View Paper
HT suppressed the increased expression of CKLF1 and NF-κB activation caused by CDDP , attenuating followed inflammatory response manifested by declined levels of TNF-α and IL-1β.
The protective effects of HT against CDDP-induced injury were partly reversed on CKLF1 overexpressed … cells, which shown by decreased cell viability and increased activation of NF-κB. HT also up-regulated the activities … and SOD decreased by CDDP , and inhibited the increased production … and NO induced by CDDP.
International immunopharmacology  •  2021  |  View Paper