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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Cisplatin
supplement:
Hydroxytyrosol
Research Papers that Mention the Interaction
“ HT alleviated the levels of reactive oxygen species in both untreated state and after cisplatin stimulus.”
“…,HT at concentration of 100 μM decreased the cell viability of HEI-OC1 from 100 ± 17.38% in control group to 50.17 ± … ± 0.050 in the control group to 1.24 ± 0.18, 0.85 ± 0.18 in the group treated with 30 μM cisplatin , as well …, respectively.”
Hydroxytyrosol enhances cisplatin-induced ototoxicity: Possible relation to the alteration in the activity of JNK and AIF pathways.“ HT suppressed the increased expression of CKLF1 and NF-κB activation caused by CDDP , attenuating followed inflammatory response manifested by declined levels of TNF-α and IL-1β.”
“The protective effects of HT against CDDP-induced injury were partly reversed on CKLF1 overexpressed … cells, which shown by decreased cell viability and increased activation of NF-κB. HT also up-regulated the activities … and SOD decreased by CDDP , and inhibited the increased production … and NO induced by CDDP.”
Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis.
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