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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Cisplatin
supplement:
Hesperidin
Research Papers that Mention the Interaction
“Two other flavonoids tested, i.e., rutin (3-rhamnosylglucoside of quercetin) and hesperidin [7-b rutinoside of hesperetin (3'-5-3-hydroxy-4-methoxyflavone)] were ineffective both alone and in combination with CDDP.”
Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth.“Conclusion: CP had severe dose-limiting toxic effects and HP treatment can be beneficial against the toxic ocular effects of CP.”
“On the other hand, HP treatment prevented histopathological effects of CP.”
“Results: The results demonstrated that CP caused a significant increase in thiobarbituric acid reactive substances (TBARS) levels and decrease of glutathione levels and antioxidant enzyme activity (catalase, superoxide dismutase and glutathione peroxidase) in eye tissues compared to other groups, HP prevented these effects of CP.”
“Thus, it appears that co-administration of HP with CP may be a useful approach to attenuate the negative effects of CP on the eye.”
Toxic effects of systemic cisplatin on rat eyes and the protective effect of hesperidin against this toxicity
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