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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Guanidines
Research Papers that Mention the Interaction
“Even CDDP bifunctionally bound to two adjacent guanines in the same DNA strand, which is considered to be a very stable adduct, was partly reversed.”
Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate.“Examples include cisplatin , which forms a covalent adduct with guanines , and doxorubicin, which traps a cleavage intermediate between topoisomerase II and torsionally strained DNA.”
Combinatorial identification of a novel consensus sequence for the covalent DNA-binding polyamide tallimustine.“At low levels of DNA-modification (cis-Pt:nucleotide = 1:50-1:1000) the intrastrand cross-link of cis-Pt with two guanines consisted of 60-70% of the total platination of DNA.”
“The main adduct was shown to be an intrastrand cross-link of cis-Pt bound to the N-7 atoms of two neighboring guanines.”
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