Possible Interaction: Cisplatin and Glycine

“However, the treatment using cisplatin , camptothecin, and SAHA was considered to be highly responsible for the perturbation of glycine , serine and threonine metabolism, and cysteine and methionine metabolism.”

“ Glycine has been shown to protect against cisplatin ( CP ) nephrotoxicity in rats and to enhance the in vitro expression of heat-shock protein (hsp) 70 in renal epithelial cells following sublethal heat shock.”

“Semiquantitative histological study revealed a marked decrease in proximal tubular injury at the juxtamedullary and outer medullary regions among animals treated with glycine and CP compared to those animals treated with CP alone.”

“We hypothesized that the protective effect of glycine against CP nephrotoxicity may be due to an up-regulation of Hsp 70 protein expression.”

“The findings of this study suggest that glycine can block the acute falls in RBF and CIN produced by cisplatin by a mechanism which involves the production of NO.”

“to rats which received cisplatin and glycine significantly inhibited the reno‐protective effect of glycine.”

“ Glycine also attenuated the weight loss, polyuria, increased fractional excretion of sodium and potassium, decreased urinary osmolality, and renal glycosuria observed in control, saline-treated rats after cisplatin , while substantially decreasing the percentage of S3 tubules with evident morphological injury.”

“Plasma concentration of glycine rose to 3.5 mmol per liter at the time cisplatin was injected.”

“The administration of L-alanine or the delayed infusion of glycine , starting one hour after cisplatin was given, did not prevent cisplatin toxicity.(ABSTRACT TRUNCATED AT 250 WORDS)”

“In this study interaction between glycine and cisplatin was explored.”

“Preincubation of RCS with 1 mM glycine or L-arginine 1 h before CDDP addition significantly attenuated the oxidative stress and tubular necrotic effects of CDDP.”

“We have investigated the possible modulatory effect of glycine and L-arginine on oxidative stress and necrosis induced by CDDP as well as on CDDP uptake by kidney.”