Possible Interaction: Cisplatin and Glutamine

“Notably, glutamine starvation has a synergistic effect with cisplatin , a component of the current medulloblastoma chemotherapy.”

“Notably, glutamine reduced the cisplatin-induced expression of organic cation transporter 2 (OCT2) and cisplatin accumulation.”

“In Caco-2 cells, cisplatin significantly increased GLN transport and the expression of GLN transporter ASCT2 messenger RNA and protein.”

“Furthermore, glutamine starvation decreased the GSH levels and CDDP resistance in A2780cis cells.”

“ Glutamin , concentrations higher than 1000 mM/… the third day after cisplatin administration have a high predictive value about getting renal failure; so, it is suggested this could be a early … cisplatin nephrotoxicity before the serum creatinine is elevated, in order to get an early and suitable treatment of it.”

“Conclusion: These results indicates that CDDP enhances the increase in blood ammonia level by glutamine supplementation without correlating with primary parameters for hepatic/renal dysfunction.”

“We conclude that glutamine is able to prevent genotoxic and clastogenic damages caused by cisplatin.”

“Pretreatment of rats with glutamine substantially inhibited the increase in the levels of renal glutathione induced by cisplatin 24h after the i.p.”

“ Glutamine significantly reduced (by about 48%) the clastogenicity of cisplatin in rat bone marrow cells.”

“The antioxidant action of glutamine presumably modulates the clastogenic action of cisplatin.”

“ Glutamine prevents cisplatin nephrotoxicity by inhibiting the oxidative stress in kidney cell apoptosis.”