Possible Interaction: Cisplatin and Glucose

“Incubation of drug-sensitive cells in low glucose medium induced the expression of SIRT1 and increased cellular resistance to cisplatin.”

“Addition of glucose in the medium inhibited the enhancement of cisplatin accumulation in KCP‐4 cells by 2,4‐dinitrophenol.”

“ Cisplatin treatment, similar to regional capsaicin desensitization of the anterior hepatic plexus, produced a significant decrease in insulin-stimulated uptake of 2-deoxy-D [L-14C] glucose in cardiac and gastrocnemius muscle with no effect on percentage suppression of endogenous glucose production by hyperinsulinaemia.”

“Decreased urinary levels of glucose , sodium and potassium reflected a protective action against the renal dysfunction caused by cisplatin.”

“… cisplatin … D-glucose transport was inhibited correlating with the degree of weight loss; (3) contraluminal PAH transport was also decreased in correlation to the loss of body … loss; (5) sulfofluorescein (SF) excretion in the urine was reduced by 43%, and (6) accumulation of SF into cortical tissue was augmented.”

“We found that D-glucose can inhibit the effects of cisplatin on tumor spheroids, and cisplatin caused severe autophagy in 3D tumor spheroids compared to 2D monoculture cells.”

“Although cisplatin per se slightly decreased the respiration of yeast cells grown in glucose , it did not disturb the mitochondrial chemiosmotic gradient.”