Possible Interaction: Cisplatin and Ginseng

“All these findings suggested that the dosage of ginseng traditionally used for health protection should be adjusted when it was prescribed together with cisplatin in the treatment of cancer.”

“Ginseng is often prescribed together with cisplatin for treatment of cancer, but the interaction between ginseng and cisplatin is still unknown.”

“In this study, the histopathological changes and elevated levels of serum creatinine (CRE) and urea nitrogen (BUN) caused by cisplatin were significantly diminished by AGBE treatment.”

“Oxidative stress caused by cisplatin , evidenced by increases in kidney tissues malondialdehyde (MDA) content, cytochrome P450 E1 (CYP2E1), renal 4-hydroxynonenal (4-HNE) levels and decreases of glutathione (GSH) and superoxide dismutase (SOD) contents, was significantly ameliorated by AGBE pretreatment.”

“In this study, pharmacological methods have been used to prove that RG can inhibit cisplatin intestinal toxicity by activating the PI3K/AKT signaling pathway to inhibit apoptosis and by antagonizing the MAPK-mediated autophagy pathway.”

“ Ginseng co-treatment with cisplatin reduced its renal damage, oxidative stress, DNA fragmentation and induced DNA repair processes.”

“ Ginseng extract also inhibited the expression of caspase‐3 and poly‐ADP‐ribose polymerase related to cisplatin‐induced apoptosis because a major mechanism of cisplatin‐induced toxicity involves ROS production.”

“Pretreatment with 2.5 mg/mL of ginseng extract prior to application of 20 μm of cisplatin significantly increased cell viability after 48 h of incubation in auditory cells.”

“Thus, Korean red ginseng extract can play both an anti‐apoptotic and anti‐oxidative role on cisplatin‐induced ototoxicity in an auditory cell line.”

“Administration of ginseng together with cisplatin improved the hepatic dysfunctions and damage caused by cisplatin.”