Possible Interaction: Cisplatin and Fish Oils

“The administration of FO and/or SeNPs might be useful for preventing nephrotoxicity which can be caused by CP and radiotherapy during the treatment of various malignancies.”

“… FO and/… of CP and exposure to γ-radiation significantly reduced CP- and γ-radiation-induced high levels of serum urea and creatinine and renal tumor necrosis … and cyclooxygenase-2, also they significantly prevented renal total antioxidant capacity levels decrease and ameliorated the levels of most studied trace elements.”

“The results showed that treatment with FO may protect against the negative ocular effects of CP.”

“In conclusion, FO supplementation had significant beneficial effects against CP toxicity on male reproductive system and toxic effects of CP can be prevented by FO treatment.”

“On the other hand, FO treatment prevented oxidative, histopathological and spermatological effects of CP and reversed side effects of CP.”

“ FO feeding to CP treated rats markedly enhanced resistance to CP-elicited deleterious effects.”

“However, concurrent FO treatment prevented the negative oxidative and histopathological effects of CP.”

“In conclusion, CP treatment can cause hepatotoxicity in rats, but dietary supplementation with FO can attenuate the oxidative and histological changes caused by CP.”

“Thus, it can be concluded that the consumption of GSPE or FO might be useful for preventing nephrotoxicity caused by cisplatin treatment.”

“A single oral dose of 100ul of two different commercially available fish oil products or algae extracts resulted in neutralization of the anti-tumor effects of cisplatin in two models; cisplatin 71 mm3 (SEM 5) vs cisplatin + fish oil 294 mm3 (SEM 49).”