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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Epinephrine
Research Papers that Mention the Interaction
“Here, we reported that adrenaline increased the cell proliferation and decreased the cisplatin induced apoptosis in HT29 cells.”
Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155.“By decreasing drug drainage through the peritoneal and tumoral vascular networks, epinephrine increases the penetration of cisplatin and oxaliplatin into the metastatic peritoneal tumor nodules.”
“▲ The vasoconstrictor action of epinephrine limits the diffusion of cisplatin into the systemic circulation.”
“ epinephrine enhances tumour penetration and anti-cancer activity of i.p.-administered cisplatin in rats with peritoneal carcinomatosis.”
Pre-clinical study of the epinephrine-cisplatin association for the treatment of intraperitoneal carcinomatosis.“DHD/K12/PROb colon tumors or by atomic absorption spectrometry in DHD/K12/PROb peritoneal tumors was 4‐ to 12‐fold higher when epinephrine was added to local cisplatin.”
“5049 Background: IP epinephrine (EPI) has been shown to enhance the accumulation and antitumor activity of IP cisplatin (CDDP) in rats with peritoneal carcinomatosis (Duvillard et al., Int J Cancer, 1999).”
Phase I study of intraperitoneal (IP) epinephrine in association with IP cisplatin in recurrent peritoneal carcinomatosis.
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