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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Cisplatin
supplement:
Epigallocatechin
Research Papers that Mention the Interaction
“Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM).”
Suppressive Effects of EGCG on Cervical Cancer“ EGCG enhanced the effect of cisplatin and oxaliplatin-induced autophagy in DLD-1 and HT-29 cells, as characterized by the accumulation of LC3-II protein, the increase of acidic vesicular organelles (AVOs), and the formation of autophagosome.”
“Our findings suggest that combining EGCG with cisplatin or oxaliplatin could potentiate the cytotoxicity of cisplatin and oxaliplatin in colorectal cancer cells through autophagy related pathway.”
“Treatment of DLD-1 and HT-29 cells with EGCG plus cisplatin or oxaliplatin showed a synergistic effect on inhibition of cell proliferation and induction of cell death.”
“Furthermore, EGCG significantly reduced cisplatin-induced weight loss from 24.7-26.3% ( cisplatin treatment) to 10.8-11.6% (cisplatin plus EGCG treatment) (P < 0.01).”
“for 10 weeks; group 4, cisplatin plus EGCG treatment EGCG was started 2 weeks before cisplatin treatment).”
(-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice.
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