Possible Interaction: Cisplatin and Emodin

“Furthermore, anti-tumor compounds, such as curcumin, emodin , chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described.”

“Co-treatment of Emodin and Cisplatin increased chemosensitivity by inhibiting the expression of drugresistant genes through reducing the ROS levels in endometrial cancer cells.”

“In an endometrial cancer xenograft murine model, the tumor size was reduced and animal survival time was increased by co-treatment of Emodin and Cisplatin.”

“In addition, emodin could sensitize CDDP , via inhibition of expression of ABCG2, to overcome chemoresistance of SP cells.”

“Cotreatment with emodin and cDDP inhibited the tumor growth in vivo by increasing tumor cell apoptosis.”

“Together, these results suggest that emodin could act as an adjunct to enhance the anticancer effect of cDDP likely through ROS-related downregulation of MRP1 expression, and may be of therapeutic potential in cDDP-refractory ovarian carcinomas.”

“ Emodin augmented the cisplatin‐induced inhibition of antioxidant enzymes (catalase, glutathione peroxidase, glutathione S‐transferase, glutathione reductase and superoxide dismutase).”

“These results suggest that emodin has the potential to be used as an adjunct therapeutic agent in patients receiving cisplatin treatment.”

“When emodin was added to the cell culture at the concentration of 10 μg/ml, the drug resistance was reduced from 21 folds to 2.86 folds for adriamycin, and from 11 folds to 1.79 folds for cisplatin.”

“ConclusionThe results demonstrate that co-exposure of tumor cells to emodin or DRB with cisplatin inhibits platinum drug uptake by impacting the hCtr1 transporter and, thereby, reduce the cytotoxicity of cisplatin.”

“The PKI emodin , for instance, can produce mixed results when combined with cisplatin , and we have sought a biochemical pharmacologic explanation for the negative cytotoxic effects.”

“Furthermore, the combination of emodin with cisplatin , doxorubicin or etoposide (VP16) synergistically inhibited the proliferation of HER-2/neu-overexpressing lung cancer cells, whereas low doses of emodin, cisplatin, doxorubicin, or VP16 alone had only minimal antiproliferative effects on these cells.”

“This was markedly lessened when CP was given simultaneously with emodin.”

“Taken together, the results from the present study demonstrated that emodin can increase A549 and H460 cell sensitivity to cisplatin by inhibiting Pgp expression.”