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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cisplatin and Diindolylmethane

Research Papers that Mention the Interaction

Importantly, diindolylmethane treatment potentiated the effects of cisplatin in SKOV-3 cells by targeting STAT3.
Oral administration of 3 mg diindolylmethane per day and subsequent administration of cisplatin substantially inhibited in vivo tumor growth.
BMC Medicine  •  2012  |  View Paper
Furthermore, DIM in combination with cisplatin drastically reduced the phosphorylation of JAK2 when compared to cisplatin alone.
Drug discoveries & therapeutics  •  2012  |  View Paper
DIM pretreatment of pancreatic cancer cells led to a significantly increased apoptosis (P < 0.01) with suboptimal concentrations of chemotherapeutic agents ( cisplatin , gemcitabine, and oxaliplatin) compared with monotherapy.
Cancer research  •  2009  |  View Paper