Possible Interaction: Cisplatin and Diallyl Trisulfide

“Moreover, DATS in combination with DDP exhibited enhanced anti-tumor activity via induction of apoptosis.”

“These studies provide supports that DATS might be a potential candidate for combination with DDP in cancer treatment.”

“In the current study, we attempted to elucidate the chemopreventive mechanisms of DATS in human gastric cancer BGC-823 cells in vitro, and to investigate whether DATS could enhance the anti-tumor efficacy of DDP and improve quality of life in BGC-823 xenograft mice in vivo.”

“Interestingly, combined administration of DATS (30 mg·kg−1·d−1, ip) with DDP (5 mg/kg, every 5 d, ip) exhibited enhanced anti-tumor activity with fewer side effects.”

“This study provides evidence that DATS exerts anticancer effects and enhances the antitumor efficacy of DDP , making it a novel candidate for adjuvant therapy for gastric cancer.”

“Hepatocellular enzymes for metabolic activation of indirect mutagens may not be involved in the enhancement of UDS-induction since DAT also increased UDS level induced by direct mutagen DDP.”

“Results showed that MMC (1-10 mumol/L), CP (0.316-3.16mmol/L), and ….16-31.6mumol/L) resulted in a significant induction of dose-dependent UDS and that DAT (0.5-4.0 mumol/L) significantly … of UDS by MMC, CP and DDP while DAT … did not.”