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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Diallyl Disulfide
Research Papers that Mention the Interaction
“ DADS significantly decreased CisPt-induced nephrotoxicity as evaluated by histology and by seric urea ( CisPt : 11.05 ± 3.59; CisPt/DADS: 6.53 ± 1.74) and creatinine (CisPt: 24.74 ± 3.03; CisPt/DADS: 14.83 ± 2.07).”
Diallyl Disulfide Prevention of Cis-Diammine Dichloroplatinum–Induced Nephrotoxicity and Leukopenia in Rats: Potential Adjuvant Effects“Surprisingly, a co-administration of OSC with cisplatin, an anticancer drug, significantly increased Mrp2 gene and protein expression (by 30-fold), suggesting that DADS could potentiate the effects of cisplatin.”
“Administration of DADS with cisplatin could enhance GSH and GST activity and lower cisplatin-induced nephrotoxicity.”
“Furthermore, DADS treatment reversed the effect of cisplatin on GSH and GST activity both in liver and kidney.”
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