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Last Updated: 2 years ago

Possible Interaction: Cisplatin and Cysteine

supplement:

Cysteine

Research Papers that Mention the Interaction

Diethyldithiocarbamate, potassium cyanide (KCN), sodium thiocyanate, L-methionine, N-acetyl-L-cysteine, 2-aminoethanethiol, L-cysteine , L-lysine, L-histidine, and L-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum(II)-protein binding in the in vitro model system.
Cancer research  •  1984  |  View Paper
However, combination treatment of cysteine (precursor for glutathione synthesis) plus cisplatin resulted in an improvement in the glutathione levels and decrease in hematological toxicities.
Cell Biology and Toxicology  •  2004  |  View Paper
Addition of cysteine and vitamin E, Crocus sativus and Nigella sativa in combination with cisplatin partially prevented many changes in the activities of serum enzymes.
Journal de pharmacie de Belgique  •  1998  |  View Paper
Reaction of DDP with glutathione (GSH), cysteine , or methionine for up to 24 hr led to concentration- and time-dependent loss of its toxic effects, whereas dissolution of DDP alone did not alter its reduction of viability or protein synthesis rate in LLC-PK1 cells.
Biochemical pharmacology  •  1990  |  View Paper
Complexing cis-platinum with cysteine considerably intensified the entire spectrum of effects of cis-platinum in the kidney.
The Biochemical journal  •  1986  |  View Paper
Regarding KYSE150 cells, the secretion of Cys C was also enhanced by co-treatment of CDDP or 5-FU with DEX, although it was not affected by the co-administration of DEX and mifepristone, a glucocorticoid receptor antagonist.
Biomedical reports  •  2013  |  View Paper
We propose that cisplatin inhibits intein activity by modifying at least one conserved cysteine residue that is required for splicing.
The Journal of Biological Chemistry  •  2010  |  View Paper
Reaction between cisplatin and L-cys yielded initially 4 adducts of which only 2 were stable and detectable after 24 hours incubation; their structures corresponded to bis-platinum cysteinyl adducts.
International journal of clinical pharmacology and therapeutics  •  2001  |  View Paper