Possible Interaction: Cisplatin and Cysteine

“Diethyldithiocarbamate, potassium cyanide (KCN), sodium thiocyanate, L-methionine, N-acetyl-L-cysteine, 2-aminoethanethiol, L-cysteine , L-lysine, L-histidine, and L-arginine demonstrated variable capacity to inhibit reaction of cisplatin with protein and to reverse bidentate platinum(II)-protein binding in the in vitro model system.”

“However, combination treatment of cysteine (precursor for glutathione synthesis) plus cisplatin resulted in an improvement in the glutathione levels and decrease in hematological toxicities.”

“Addition of cysteine and vitamin E, Crocus sativus and Nigella sativa in combination with cisplatin partially prevented many changes in the activities of serum enzymes.”

“Reaction of DDP with glutathione (GSH), cysteine , or methionine for up to 24 hr led to concentration- and time-dependent loss of its toxic effects, whereas dissolution of DDP alone did not alter its reduction of viability or protein synthesis rate in LLC-PK1 cells.”

“Complexing cis-platinum with cysteine considerably intensified the entire spectrum of effects of cis-platinum in the kidney.”

“Regarding KYSE150 cells, the secretion of Cys C was also enhanced by co-treatment of CDDP or 5-FU with DEX, although it was not affected by the co-administration of DEX and mifepristone, a glucocorticoid receptor antagonist.”

“We propose that cisplatin inhibits intein activity by modifying at least one conserved cysteine residue that is required for splicing.”

“Reaction between cisplatin and L-cys yielded initially 4 adducts of which only 2 were stable and detectable after 24 hours incubation; their structures corresponded to bis-platinum cysteinyl adducts.”