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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“Importantly, the α-lipoic acid had to be administered prior to exposure to cisplatin or paclitaxel in order to prevent neurotoxicity.”
“ α-lipoic acid had neuroprotective effects with both cisplatin and paclitaxel toxicity in cell culture.”
Alpha-lipoic acid and frataxin: A new indication for an old antioxidant?“Conclusions: Apoptosis and oxidant effects of Cisp were increased by activation of TRPV1 channels, but its action on the values was further increased by the ALA treatment.”
“The aim of this study was to evaluate if a combination therapy of ALA with Cisp can alter the effect of this chemotherapy drug in the MCF-7 breast cancer cells.”
“ConclusionThis strategy of oral ALA administration was ineffective at preventing neurotoxicity caused by oxaliplatin or cisplatin.”
“ LA attenuated the translocation of mitochondrial bax, reduced the release of cytochrome c, and decreased the expression of caspase-3 and caspase-9 serially in cisplatin nephrotoxicity.”
Alpha-Lipoic Acid Attenuates Cisplatin-Induced Tubulointerstitial Injuries through Inhibition of Mitochondrial Bax Translocation in Rats“Plasma creatinine increased (677% of control) following cisplatin administration alone which was decreased by lipoic acid in a dose-dependent manner.”
“In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity.”
Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity☆
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