Possible Interaction: Cisplatin and Allicin

“Furthermore, allicin synergistically enhances growth inhibitory activity of low dose cisplatin to effectively overcome hypoxia induced cisplatin resistance in A549 cells.”

“Our results demonstrate that allicin plays an effective role in protecting stria vascularis injury induced by cisplatin by inhibiting caspase-dependent, as well as caspase-independent PARP-1-AIF-mediated apoptotic pathways.”

“Stria vascularis injury was induced in mice by intraperitoneal injection of cisplatin , which was significantly prevented by pretreatment with allicin.”

“In conclusion, both allicin and AA showed significant nephroprotective effects against CDDP intoxication and their combination exhibited better protection than either agent alone.”

“Therefore, allicin may be useful in preventing oto‐vestibulotoxicity mediated by cisplatin.”

“These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase‐dependent and caspase‐independent apoptotic pathways.”

“All data suggested that allicin could prevent hearing loss induced by cisplatin effectively, of which allicin protected SGNs from apoptosis via mitochondrial pathway while protected OHCs and supporting cells (SCs) from apoptosis through p53 pathway.”

“ Allicin markedly protected SGN mitochondria from damage and releasing cytochrome c, and significantly reduced pro‐apoptosis factor expressions activated by cisplatin , including Bax, cleaved‐caspase‐9, cleaved‐caspase‐3and p53.”

“ Allicin reduce the oxidative stress response caused by cisplatin in the cochlea.”

“The present study demonstrated that combined use of allicin and cisplatin or carboplatin resulted in an enhanced growth inhibitory effect on SW1736 and HTh-7 cells.”