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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cisplatin
supplement:
3-Nitrotyrosine
Research Papers that Mention the Interaction
“Treatment with CDDP and NO increased amounts of nitrotyrosine protein adducts , indicative of peroxynitrite formation, and promoted the induction of AKR1B10, inferring a relationship between peroxynitrite formation and the enzyme upregulation in the cells.”
Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome“In addition, cisplatin treatment induced a significant decrease in the expression of Lmo4 protein and a significant increase in nitrotyrosine levels, in the hair cells.”
Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation.“ Cisplatin treatment increased the levels of nitrotyrosine and active caspase 3 in UBOC1 cells, which was detected by immunocytochemical and flow cytometry analysis, respectively.”
“ Cisplatin significantly increased inflammation (leukocyte infiltration, CXCL1/2, MCP-1, TNFalpha, and … NOX2, NOX4, and NOX1 and enhanced ROS generation, iNOS expression, nitrotyrosine formation , and apoptotic and poly(ADP-ribose) polymerase-dependent cell death in the kidneys … BUN and creatinine levels) 3 days after the administration of the drug.”
“The cisplatin injection also increased 3-nitrotyrosine and 4-hydroxy-2-nonenal immunostaining in renal cortex and medulla.”
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