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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ciprofloxacin
supplement:
Quinidine
Research Papers that Mention the Interaction
“Based on these findings, the authors hypothesized that ciprofloxacin may decrease the clearance of quinidine , a drug which also undergoes oxidative metabolism.”
The Effect of Ciprofloxacin on the Pharmacokinetic and ECG Parameters of Quinidine“In the presence of quinidine , verapamil and cyclosporin (substrates of the P‐glycoprotein (P‐gp)), plasma AUCs of ciprofloxacin were 1.5–2 fold increased, while biliary clearance (1.5–2 fold), intestinal overall and net clearances (2–4 fold and 1.5–8 fold respectively) decreased.”
Active intestinal elimination of ciprofloxacin in rats: modulation by different substrates
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