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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Ciprofloxacin
supplement:
Glutathione
Research Papers that Mention the Interaction
“SOD and CAT activities and GSH levels significantly decreased in the ciprofloxacin group.”
Beneficial effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin in rats“Taking the data together, it can be concluded that GSH supplementation influences the expression of genes of multiple stress response pathways apart from its effect(s) at the physiological level to counter the action of ciprofloxacin in E. coli.”
Transcriptome Profiling Reveals Interplay of Multifaceted Stress Response in Escherichia coli on Exposure to Glutathione and Ciprofloxacin“The results indicated that glutathione increased the total active efflux, thereby partially contributing to glutathione-mediated neutralization of ciprofloxacin 's antibacterial action in E. coli.”
“There was substantial depletion in both SOD and glutathione levels particularly with ciprofloxacin.”
“The association of glutathione with ciprofloxacin or gentamicin significantly reduced the value of the minimum inhibitory concentration (MIC) in resistant S. aureus 22, measured using the macrodilution method, with a concomitant increase of intracellular ROS and a decrease of extracellular ROS.”
“On exposure to CPFX , both EROD and GSH decreased at low CPFX concentrations (<5.0 mg/L) and increased at high CPFX concentrations (>12.5 mg/L), and CAT and GST exhibited induction at low concentrations and inhibition at high concentrations.”
“Among the antioxidants checked, glutathione and ascorbic acid provided substantial protection against ciprofloxacin.”
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