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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Ciprofloxacin
supplement:
Ferrous Sulfate
Research Papers that Mention the Interaction
“The AUC and peak plasma concentration of ciprofloxacin were reduced by 57% (P < 0.001) and 54% (P < 0.01), respectively, by ferrous sulphate.”
“We recommend that norfloxacin and ciprofloxacin should not be taken together with ferrous sulphate.”
The effect of ferrous sulphate on the absorption of norfloxacin, ciprofloxacin and ofloxacin.“Peak serum ciprofloxacin concentrations and area under … curve (AUC) were significantly reduced when ciprofloxacin was administered … 300 mg ferrous sulphate (3.0 vs 2.0 mg l-1, P less than 0.05 and 12.3 vs 6.7 mg l-1 h, P less than 0.01, respectively).”
“ Ferrous sulfate and multivitamins with zinc significantly impaired the absorption of ciprofloxacin.”
“The absorption of ciprofloxacin has been reported to be impaired by concomitant administration of ferrous sulphate.”
Effects of Ascorbic Acid on Interactions between Ciprofloxacin and Ferrous Sulphate, Sodium Ferrous Citrate or Ferric Pyrophosphate, in Mice
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