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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ciprofloxacin
supplement:
Edetic Acid
Research Papers that Mention the Interaction
“Furthermore, we found that the matrix destablilizers EDTA and DNaseI increase the susceptibility of NTHi biofilms to ampicillin and ciprofloxacin.”
The biofilm matrix destabilizers, EDTA and DNaseI, enhance the susceptibility of nontypeable Hemophilus influenzae biofilms to treatment with ampicillin and ciprofloxacin“EDTA plus antibiotics reduced the colony counting … 103 CFU/mL. In vivo, EDTA … ciprofloxacin had a significantly lower mean CFU/g of lung tissue (EDTA + ciprofloxacin 1.3 ± 0.19; EDTA 4.…; ciprofloxacin 4.2 ± 0.47), and lung lesions were less severe compared with the single treatment groups.”
In vitro and in vivo activity of EDTA and antibacterial agents against the biofilm of mucoid Pseudomonas aeruginosa“Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin , and azithromycin.”
In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.“A low concentration of ethylene diamine tetraacetie acid (EDTA) did positively affect the degradation rate of CIP.”
“… EDTA decreased … of ciprofloxacin for P. aeruginosa PAO503 and its gyrA derivative by 5- and 2-fold, respectively, and decreased the ID50 for E. coli JB5R, a … a known decrease in OmpF, by 1.4-fold but did not decrease the ID50 for the normally susceptible E. coli J53.”
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