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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Ciprofloxacin
supplement:
Copper
Research Papers that Mention the Interaction
“A novel approach to sustain ciprofloxacin CIP ) in the lungs after inhalation is to reduce its pulmonary absorption rate by its complexation with copper (CIP-Cu).”
Efficacy of Ciprofloxacin and Its Copper Complex against Pseudomonas aeruginosa Biofilms“An increase in the applied CIP decreased the free Cu ion concentration in external solution and mortalities of earthworm, while Cu contents in earthworms increased.”
Accumulation, subcellular distribution and toxicity of copper in earthworm (Eisenia fetida) in the presence of ciprofloxacin.“Previously, we demonstrated that the complexation of CIP with copper (CIP-Cu) reduces its apparent epithelial permeability and pulmonary absorption rate without affecting antimicrobial activity against Pseudomonas aeruginosa grown planktonically or as biofilms.”
In vivo Efficacy of a Dry Powder Formulation of Ciprofloxacin-Copper Complex in a Chronic Lung Infection Model of Bioluminescent Pseudomonas aeruginosa.“Different from Cu and Ca on the sand surface, Cu and Ca in solution decreased CIP sorption.”
“In clean sand where Fe/Al oxides were removed, Ca and Cu significantly promoted CIP transport by reducing the retardation factor R from 22 to <2.”
“In native sand, due to CIP's strong complexation with Fe/Al, only Cu promoted CIP transport.”
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