Possible Interaction: Cinnarizine and Calcium Supplement

“ Cinnarizine and flunarizine antagonized calcium accumulation and bound to alpha-sites.”

“The antivasoconstrictor activity of the drugs cinnarizine and flunarizine is considered in relation to their inhibitory action on calcium ion flux mechanisms.”

“Our aim was to test in patch-clamp experiments (conventional whole-cell mode) whether cinnarizine , by reducing Ca2+ influx, inhibited Ca2+ and pressure-sensitive K+ currents in vestibular type-II hair cells of guinea pigs.”

“… Ca2+ (… cinnarizine and pimozide, but not that of verapamil and diltiazem, the weak activity of some of the antagonists as relaxants of Ca2+-induced contractions can … potency of drugs as “Ca2+-antagonists” are discussed and it is proposed that three subgroups of drugs may exist within the overall classification.”

“Both cinnarizine and lidoflazine blocked stimulated Ca uptake in a concentration-dependent manner without affecting the % inactivation.”

“Chronic treatment with cinnarizine , an organic Ca2+ channel antagonist, alters both D1 and D2 receptor densities, with a higher sensitivity of the D1 subtype.”

“The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca(2+)-mediated.”

“ Cinnarizine is proposed to block both MTX-elicited mechanisms, the first by blockade of calcium channels and the second by blocking 1,4,5-inositol trisphosphate-induced release of internal calcium.”

“ Cinnarizine's mechanism seems to be related to its antagonistic action to Ca in smooth muscle, but not to the transport of Ca in releasing the anaphylactic chemical mediators in mast cells and other target cells.”

“These results support the hypothesis that nifedipine, gallopamil, diltiazem and cinnarizine inhibit Ca2+‐ and KCl‐induced tension development of rat uterus by reduction of Ca2+ influx.”