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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cimetidine
supplement:
Vitamin D
Research Papers that Mention the Interaction
“The data suggest that short-term treatment with cimetidine could potentially perturb vitamin D metabolism in man.”
Effect of cimetidine on hepatic vitamin D metabolism in humans.“Feeding 500 and 750 mg of CIMET significantly decreased total egg production in hens fed either level of vitamin D3 , but no differences were observed at lower CIMET levels.”
Effect of cimetidine on eggshell quality and plasma 25-hydroxycholecalciferol in laying hens.“Because previous studies indicated that cimetidine (CIMET) and isoniazid (ISON) may inhibit vitamin D metabolism in both rats and humans, experiments were conducted to evaluate the influence of these drugs on growth and bone development in male broiler chicks.”
“The interaction between vitamin D3 and CIMET was significant for BWG, FCB, TA, and TBF.”
“Both cimetidine and isoniazid inhibited vitamin D 25-hydroxylase activity in vitro.”
“Vitamin D 25-hydroxylase activity was depressed to 75%, 65%, and 55% of control values by cimetidine at 3, 6, …%, 53%, and 35% by isoniazid at 1, 5, and 10 mmol/L. In vivo intraperitoneal administration of 120 mg/kg cimetidine … vitamin D 25-hydroxylase activity … activity by 26%.”
“The half-life of 25(OH)D3 and/or 1,25(OH)2D3 was found to be impacted by cimetidine ; rosuvastatin; prednisone and possibly some chemotherapy drugs.”
Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review
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