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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cimetidine
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“The results show that the supplementation of rats with vitamin B12 during cimetidine treatment increases sperm concentration and exerts a potential effect in the recovery of spermatogonia and spermatocytes.”
Vitamin B12-induced spermatogenesis recovery in cimetidine-treated rats: effect on the spermatogonia number and sperm concentration“However, vitamin B12 supplement is able to stimulate spermatogenesis and restore the number of Sertoli cells, softening the harmful effect of cimetidine on spermatogenesis.”
“Treatment of gastric ulcer with cimetidine reduces acid secretion and interferes in the vitamin B12 absorption.”
“The administration of vitamin B12 to male rats prevents the androgenic failure and counteracts the damage inflicted by cimetidine upon sperm quality, indicating that this vitamin may be used as a therapeutic agent to maintain the androgenic status and the sperm quality in patients exposed to androgen disrupters.”
Vitamin B12 Prevents Cimetidine-Induced Androgenic Failure and Damage to Sperm Quality in Rats
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